Hexenal Derived from Dietary n-3 Polyunsaturated Fatty Acids Induces Anti-Oxidative
Enzyme Heme Oxygenase-1 in Multiple Organs.” Biochemical and Biophysical Research
Communications. Vol. 443, no. 3. (2014): 991–996.
84.
Kumar H, Kim IS, More SV, Kim BW, Choi DK. “Natural Product-Derived Pharmacological
Modulators of Nrf2/ARE Pathway for Chronic Diseases.” Natural Products Reports. Vol. 31,
no. 1. (January 2014): 109–139.
85.
Lewis KN, Mele J, Hayes JD, Buffenstein R. “Nrf2, a Guardian of Healthspan and
Gatekeeper of Species Longevity.” Integrative and Comparative Biology. Vol. 50, no. 5.
(November 2010): 829–843.
86.
Kapeta S, Chondrogianni N, Gonos ES. “Nuclear Erythroid Factor 2-Mediated Proteasome
Activation Delays Senescence in Human Fibroblasts.” Journal oƒ Biological Chemistry. Vol.
285, no. 11. (March 12, 2010): 8171–8184.
87.
Jódar L, Mercken EM, Ariza J, Younts C, González-Reyes JA, Alcaín FJ, Burón I, de Cabo R,
Villalba JM. “Genetic Deletion of Nrf2 Promotes Immortalization and Decreases Life Span
of Murine Embryonic Fibroblasts.” Journals oƒ Gerontology. Series A: Biological Sciences
and Medical Sciences. Vol. 66A, no. 3. (March 2011): 247–256.
88.
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T,
Saya H, Hara E. “Mitogenic Signalling and the p16INK4a-Rb Pathway Cooperate to Enforce
Irreversible Cellular Senescence.” Nature Cell Biology. Vol. 8, no. 11. (2006): 1291–1297.
89.
Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Odelberg SJ. Firpo MA, Paine
R 3rd, Hoidal JR, Abel ED, Rajasekaran NS. “Impaired Transcriptional Activity of Nrf2 in Age-
Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training.” PLoS
One. Vol. 7, no. 9. (2012): e45697.
90.
Pall ML, Levine S. “Nrf2, a Master Regulator of Detoxification and also Antioxidant, Anti-
Inflammatory and Other Cytoprotective Mechanisms, Is Raised by Health Promoting
Factors.” Sheng Li Xue Bao (Acta Physiologica Sinica). Vol. 67, no. 1. (February 25, 2015): 1–
18.
91.
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S,
Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas
P, de Cabo R. “Nrf2 Mediates Cancer Protection but Not Prolongevity Induced by Caloric
Restriction.” Proceedings of the National Academy of Sciences of the United States of
America. Vol. 105, no. 7. (2008): 2325–2330.
92.
Bishop NA, Guarente L. “Two Neurons Mediate Diet-Restriction-Induced Longevity in C.
Elegans.” Nature. Vol. 447, no. 7144. (2007): 545–549.
93.
Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D. “The Role of the Antioxidant and
Longevity-Promoting Nrf2 Pathway in Metabolic Regulation.” Current Opinions in Clinical
Nutrition and Metabolic Care. Vol. 14, no. 1. (January 2011): 41–48.
94.
Martín-Montalvo A, Villalba JM, Navas P, de Cabo R. “NRF2, Cancer and Calorie
Restriction.” Oncogene. Vol. 30, no. 5. (February 3, 2011): 505–520.
95.
Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R. “Mechanisms Underlying Caloric
Restriction and Lifespan Regulation: Implications for Vascular Aging.” Circulation
Research. Vol. 102, no. 5. (March 14, 2008): 519–528.